Optimization of Carbopol 941 And HPMC on the Gel of the Bark of Strychnos lucida R.B Ethanol Extract as Hand Sanitizer
DOI:
https://doi.org/10.21776/ub.jfls.2020.004.02.02Keywords:
Gelling agent, Simplex Lattice Design, Strychnos lucida R.Br., AntibacterialAbstract
      Some research resulted that show Strychnos lucida R.Br contains compound of tannin, flavonoids, phenols, alkaloids and saponins that can be used as antibacterial. Seeing the compounds contained, one csn make an antiseptic gel. An important components in the gel preparation is gelling agent. Gelling agent is widely used because it has high stability and increases the effectiveness of the use of gel as an antibacterial. This study aims to determine the optimum composition of Carbopol 941 and HPMC in the extract of Strychnos lucida R.Br stem using the Simplex Lattice Design method. The gel was made in three formulas with a comparison of Carbopol 941 and HPMC, 100%: 0%; 50%: 50%; 0%: 100%. Next, these were tested physicochemical properties including spreading, pH, and stickiness tests. The validity of the optimization method has done before by comparing the test result and the prediction in the optimum gel formula. The results showed that the optimum composition was obtained of Carbopol 941: HPMC by 50%: 50%. Verification results compared to the prediction results it did not show different for all tests, spreading, pH, stickiness tests and antibacterial. The optimum formula for the ethanol extract of Strychnos lucida R.Br stems have the potential for strong antibacterial activity with a inhibitory zone value of 13.55 mm.
References
Bolton, S. 1997. Pharmaceutical Statistics Practical and Clinical Application, 3rd Edition, 610-619, Marcl Dekker inc, New York.
Edwars, D.L., Johnsons, C.E. 1987. Insect repellent induced toxic encephalopathy in child., Clin Pharm., VOL 6., Hal 496-498.
Erawati E., Pratiwi D., Zaky M. 2015. Pengembangan formulasi dan evaluasi fisik sediaan krim ekstrak etanol 70% daun labu siam (Sechium edule (Jacq.)Swatz). Farmagazine,Vol. 3(1).
Nazzaro F., Fratianni F., Martino, L.D., Copolla, R., & Feo, V.D. 2013. Effect of Essential Oils on Pathogenic Bacteria, J. Pharmaceuticals, 6, 1451-1471.
Nurlaela E., S N., Ikhsanudin A. 2012. Optimasi komposisi tween 80 dan span 80 sebagai emulgator dalam repelan minyak atsiri daun sere (Cymbopogon citratus (d.c) stapf) terhadap nyamuk Aedes aegypti betina pada basis vanishing cream dengan metode Simplex Lattice Design. Jurnal Ilmiah Kefarmasian 2(1): 41 – 54.
Setiawan O, Wahyuni N, Susila W.W, Rahayu A.D, Rostiawati T. 2014. Bidara Laut (Strychnos ligustrina Blume) syn. S. lucida R.Br: Sumber Bahan Obat Potensial di Nusa Tenggara Barat dan Bali. Bogor: FORDA press.
